Dermal Fillers improve the appearance of facial wrinkles and skinfolds, they do this by injecting substance into your skin to plump up the skin, which can be in the lips, cheeks, chin, hands and jawline. Dermal fillers are as effective as Botox and can last much longer. As the skin ages it loses its natural elasticity, which provides structure, Fillers replace this lost fat and collagen, giving a more youthful look.